Boehringer Ingelheim to start late-stage hepatitis C drug trial
















BOSTON (Reuters) – Boehringer Ingelheim said on Saturday it plans to initiate a late-stage clinical trial of its experimental hepatitis C treatment following promising results from earlier studies.


The company announced final data from a mid-stage trial of its treatment regimen which showed that 69 percent of patients in the study were free of the virus 12 and 24 weeks following the end of treatment.













Hepatitis C is a blood-borne infectious disease of the liver that can lead to liver failure and transplant.


Historically, hepatitis C has been treated with pegylated interferon and ribavirin, but treatment lasts as long as 48 weeks and interferon is associated with flu-like side effects.


The goal of drugmakers now, including Boehringer, Vertex Pharmaceuticals Inc, Gilead Sciences Inc and Bristol-Myers Squibb Co is to develop products that do not need to be combined with interferon. Most analysts consider Gilead to currently be at the forefront of the race.


Full results from Boehringer’s trial, known as SOUND-C2, were presented at the annual meeting of the American Association for the Study of Liver Diseases in Boston. Preliminary data were presented earlier this year.


Boehringer’s trial tested a combination of BI-201335, a protease inhibitor, BI-207127, a polymerase inhibitor, and ribivirin.


Boehringer is a privately held company headquartered in Ingelheim, Germany.


(Reporting By Toni Clarke; Editing by Marguerita Choy)


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Chelsea’s first Abramovich profit

















Chelsea Football Club has said it made a profit of £1.4m ($ 2.2m) for the financial year ending on 30 June, the first time the club has made a profit since Russian billionaire Roman Abramovich took over as owner in 2003.













The west London club also recorded a record group turnover of £255.7m.


The team, which won the Champions League last season as well as the FA Cup, are second in the Premier League.


The profit comes after a £67.7m loss in the previous financial year.


Chelsea says it is in a strong position to comply with UEFA’s Financial Fair Play criteria for the coming seasons, which require clubs over a fixed period to achieve a break-even figure when expenditure is measured against income from football-related activities.


The increase in turnover puts them above Arsenal in the money league and in fifth place in the world behind Real Madrid, Barcelona, Manchester United and Bayern Munich.


Arsenal’s figure, released two months ago, saw overall turnover fall to £243m from £255m, but profits were £30.6m.


BBC business editor Robert Peston, a Gunners supporter, said that Chelsea’s profit “challenged Arsenal’s claim that its restrained spending will put it in a stronger position for financial fair play”.


‘Improving financial performance’


Club chairman Bruce Buck said: “We will never forget that night in Munich and now we are celebrating serious progress off the field, too.


Continue reading the main story

Football is only one of Mr Abramovich’s passions. He is also an art collector, a politician and, above all, a businessman”



End Quote


“While we draw huge satisfaction from the achievements of the past 12 months, we are more than ever focused on continuing the story of on-field success supported by improving financial performance off the pitch.”


Turnover was up from £225.6m the previous financial year.


“The club also enjoyed an uplift in revenues from commercial activities including new partners and merchandising,” a Chelsea statement said.


It added: “The club also negotiated a deal with BSkyB to acquire its interest in Chelsea Digital Media Ltd (the holder of certain Chelsea media rights). This deal allows the club to have full control of our digital media strategy.”


According to their statement Chelsea made “significant profits (£28.8m) …in the transfer market”.


However, there were a number of big-money signings during the year of the accounts – for example of Eden Hazard, for about £30m, Juan Mata (£23.5m) and Gary Cahill (£7m) – without any major sales of players.


Ten trophies


The Stamford Bridge club’s statement also said that debt of some £166.6m was turned into equity during the course of the year “making Chelsea FC plc debt free”.


Mr Abramovich took control of Chelsea in June 2003, when he bought the club from then-owner Ken Bates.


Since he took over the club has won ten major trophies – the Champions League, three Premier League titles, four FA Cups, and two League Cups.


In the year ending June 2005, Chelsea posted a record financial loss of £140m (€165m).


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Twin explosions strike southern Syrian city
















BEIRUT (AP) — Syria‘s state-run news agency says two large explosions have struck the southern city of Daraa, causing multiple casualties and heavy material damage.


SANA did not immediately give further information or say what the target of Saturday’s explosions was.













The Britain-based Syrian Observatory for Human Rights says the blasts went off near a branch of the country’s Military Intelligence in Daraa.


The Observatory, which relies on a network of activists on the ground, says the explosions were followed by clashes between regime forces and rebels fighting to topple President Bashar Assad.


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Can a Fit Video Game Avatar Make You Healthier?
















Time to reconsider the stereotype of doughy, fast food-guzzling online role players in dark basements. Strongly identifying with your avatar in virtual video game worlds like “Second Life” could actually help make you healthier in the real world, research from the University of Missouri shows.


Elizabeth Behm-Morawitz surveyed 249 “Second Life” users to study how avatars — their customized virtual characters in games — affect real-world existence. She found that the amount of self presence, or identifying with a virtual representation, predicted the amount of influence an avatar had on a person’s life in the physical world. A strong sense of self-presence improved how they felt about themselves and promoted better health and well-being.  













In the study, published in the journal ”Computers in Human Behavior,” Behm-Morawitz wrote, “The avatar links the virtual to the physical body, and, through this interplay of one’s online and offline identities, the virtual may become meaningful to the physical body and self.”


For example, for people looking to lose weight, creating a fitter avatar helped them visualize being in better shape.   


Curiously, the participants weren’t specifically using “Second Life” as a fitness tool, as they might with, say, a Wii Fit game. “‘Second Life’ is a social virtual world, where play is open-ended and not specifically designed to be used as a motivational health tool,” Behm-Morawitz told TechNewsDaily in an email. “However, the findings … suggest that a person who is motivated to participate in a virtual world for social reasons is more likely to experience effects of the avatar.”


In other words, if you are into the game enough to care about how you come across online, that will motivate you to make a better impression offline, too.


[See Also: Rats Control Human Avatars]


Behm-Morawitz says the results should not be limited to “Second Life” — other virtual worlds could show the same kinds of benefits. However, virtual worlds that offer the most control over avatar design and interaction will best foster self-presence and prompt healthy behavior change.


Avatars are useful for trying on a new appearance, Behm-Morawitz said, since they pose little risk to the creator.  


Though it may seem like a throwback to the early 2000s, “Second Life” remains one of the most popular online games. In July 2012, Nielsen rated it among the top 10 PC games.  


Other studies support the new research. In an Indiana University study published in September, more people adopted healthy habits when they went through weight-loss programs delivered in a 3D virtual world than those who pursued a program in a traditional health club.  


This story was provided by TechNewsDaily, a sister site to LiveScience. Follow TechNewsDaily on Twitter @TechNewsDaily. We’re also on Facebook & Google+.


Copyright 2012 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Taylor Swift to headline “New Year’s Rockin’ Eve”
















LOS ANGELES (Reuters) – Country-pop star Taylor Swift will ring in the New Year in the United States as the headline act on TV special “New Year’s Rockin’ Eve,” which will feature a two-hour tribute to late host Dick Clark, organizers said on Friday.


Swift, whose new album “Red” racked up more than 1 million copies in first week U.S. sales, will perform live in New York’s Times Square on December 31, just before the ball drops to bring in 2013.













The New Year’s Eve music special for ABC television was hosted for four decades by legendary TV and music producer Clark before his death in April at age 82.


This year the show will be helmed again by Clark’s recent co-host – “American Idol” host and radio DJ Ryan Seacrest – under the title “Dick Clark’s New Year’s Rockin’ Eve with Ryan Seacrest,” ABC and dick clark productions said.


The evening will kick off with a two-hour tribute to the host of TV dance show “American Bandstand” that will feature clips of Clark’s long career, and remembrances by musicians and industry celebrities.


The 5-1/2 hour show will also feature other musical guests, yet to be announced, and report on New Year celebrations around the globe.


(Reporting By Jill Serjeant; Editing by Eric Walsh)


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California teen steps into rattlesnake nest, survives
















SAN DIEGO (Reuters) – A teenage California girl searching for a cell phone signal to call her mother in a rural area outside San Diego inadvertently stepped into a nest of rattlesnakes and was bitten six times, but survived.


The 16-year-old, Vera Oliphant, spent four days in the intensive care unit of Sharp Grossmont Hospital, and doctors gave her 24 vials of antivenom after she was bitten by an adult rattlesnake and five young rattlers outside her uncle’s home.













“I was trying to find a signal to call my mom and text my boyfriend,” Oliphant said on Friday, a day after she was released from the hospital following the October 27 incident.


“I didn’t see them until I already stepped on their nest and I felt them biting me.”


“My vision started to go right away. First it looked like the snakes blended into the leaves and then I started seeing black spots around the edges and I started blacking out.”


She returned to her uncle’s home in Jamul, outside San Diego, and he immediately packed her into the car and rushed her to the emergency room, she said.


On the way, she talked to her mom and her boyfriend, who told her to stay calm so the venom wouldn’t spread.


“I told my mom and my boyfriend I love them in case I don’t get to see them again,” she said.


Doctors there administered 24 vials of antivenom to quash the dangerous toxins, according to a hospital spokesman. Snakebites usually aren’t fatal, although a handful of people die in the United States each year from snake bites, including bites from rattlesnakes.


Oliphant has recovered and will be returning to classes at Chaparral High School in El Cajon on Monday. She said the next time she can’t get a signal, she will handle it differently.


“Be careful where you step,” she said. “If you don’t need to, just wait until you are somewhere that you can call people.”


(Editing By Cynthia Johnston and Todd Eastham)


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China exports accelerate in October, imports weak
















BEIJING (AP) — China‘s export growth accelerated in October in a fresh sign the world’s second-largest economy is recovering from a painful slump, but the commerce minister warned that exporters face tough conditions in coming months.


Exports rose 11.6 percent from a year earlier, up from the previous month’s 9.9 percent rate, data showed Saturday. Import growth held steady at 2.4 percent.













The improvement is a positive sign for the ruling Communist Party, which is holding a congress to hand power to younger leaders who might benefit from an economic uptick.


Still, the commerce minister warned that Chinese exporters face tough conditions ahead due to weak global demand and rising operating costs.


“The trade situation will be relatively grim in the next few months and there will be many difficulties next year,” Chen Deming told a news conference.


Analysts say a modest recovery is under way from China’s deepest downturn since the 2008 world financial crisis. But they say it will be gradual and too weak to drive global growth without improvement in the United States and Europe.


Data reported Friday showed Chinese auto sales, factory output and investment also improved in October.


Stronger exports will help manufacturers that were battered by last year’s slump in global demand. Thousands closed and survivors slashed payrolls, raising the danger of unrest as Communist leaders tried to enforce calm ahead of the leadership transition.


The import weakness meant China’s global trade surplus widened by nearly 90 percent over a year ago to $ 32 billion — the highest monthly level this year.


Chen, the commerce minister, also warned that “growing trade protectionism” might hurt exporters.


World leaders pledged after the 2008 crisis to avoid steps that might hinder trade and hamper a recovery. But Beijing and trading partners including the United States, Europe and Japan have raised tariffs on goods including autos and solar panels in a series of disputes over market access, subsidies and other issues.


Beijing set a target of 10 percent trade growth this year, but it looks increasingly unlikely the country can reach that after total trade rose only about 6 percent for the first 10 months.


Lackluster Chinese import demand reflects government curbs on lending and investment to cool inflation and overheating.


Those controls helped to crush surging prices but hurt China’s large construction industry and depressed its voracious appetite for steel beams, wiring and other materials made of imported iron ore, copper and other commodities. That is bad news for miners and other commodity exporters such as Australia and Brazil that supply China.


China’s economic growth fell to a three-and-a-half-year low of 7.4 percent in the quarter ending in September. Analysts say the slowdown probably has reached its bottom and activity should improve in the current quarter.


The government said last month it saw “steady economic growth,” suggesting there was no need for further major stimulus following interest rate cuts and higher spending on public works construction and investment by state companies.


Demand in debt-plagued Europe was so weak that the 27-nation European Union was temporarily overtaken by the United States as China’s biggest trading partner for October.


Exports to the United States rose 9.5 percent to $ 31.2 billion. China’s trade surplus with the U.S. widened by 8 percent to $ 21.6 billion.


Exports to Europe fell 5.8 percent to $ 26.4 billion, with more severe declines for some struggling economies. Italy‘s purchases of Chinese goods plunged 25.7 percent while exports to France were off 9 percent. China’s trade surplus with Europe narrowed by 17 percent to $ 10.8 billion.


___


Online:


General Administration of Customs of China (in Chinese): www.customs.gov.cn


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Syria opposition bloc elects Christian as leader
















DOHA, Qatar (AP) — Syria‘s main opposition group in exile has elected a Christian Paris-based former geography teacher as its new president.


George Sabra said Friday that his election as head of the Syrian National Council is a sign that the opposition is not plagued by sectarian divisions.













Sabra says the SNC‘s main demand is to receive weapons from the international community. The U.S. and some other foreign backers of rebels fighting the regime of President Bashar Assad have so far refused to send weapons for fear they can fall into the wrong hands.


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Dancing With The Stars Family Rallies On Twitter In Support Of Brooke Burke-Charvet Following Thyroid Cancer Diagnosis
















Members of the “Dancing with the Stars” family Tweeted their well-wishes for the show’s co-host, Brooke Burke-Charvet, who revealed on Thursday she has thyroid cancer.


Helio Castroneves, who was recently eliminated from the “All-Stars” season, said he is confident she will overcome the disease.













PLAY IT NOW: Brooke Burke-Charvet’s Sexy Lingerie Shoot!


“Hi @brookeburke, I have sure that you will win this battle. My affection for you,” the Indy driver wrote.


Brooke revealed on Thursday that she will be undergoing thyroid surgery and a thyroidectomy, and Erin Andrews, who competed in Season 10, noted she was praying for the host.


VIEW THE PHOTOS: The Lovely Brooke Burke-Charvet


“Thinking about @DancingABC friend @brookeburke..Prayers and all the best your way Brooke,” Erin wrote.


Also sending her kind words was Sabrina Bryan, who was eliminated last week on the show.


“@brookeburke hey girl!! You’re in my thoughts and prayers! Always here for you during this fight! Stay strong,” Sabrina wrote.


VIEW THE PHOTOS: Dancing With The Stars: All-Stars — Week 6


Season 13 vet Ricki Lake wrote, “@brookeburke sending huge healing love your way.”


Current contender Melissa Rycroft shared her support, Tweeting, “You’re such a strong woman, and I admire your courage. I hope you feel all the love and support behind you…We love you!”


VIEW THE PHOTOS: ‘Dancing’s’ Derek Hough


And some of the professional dancers chimed in too.


Pro Derek Hough (Brooke’s Season 7 partner) Tweeted, “Love you Brookie B. [You're] in my prayers.”


Cheryl Burke Tweeted, “I love u @brookeburke!! Stay strong. Will be praying for u and sending u lots of positive energy!”


– Jolie Lash


Copyright 2012 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Lagerfeld says Ghesquiere with Arnault “not bad idea”
















PARIS (Reuters) – Star designer Karl Lagerfeld said the departure of Nicolas Ghesquiere from Balenciaga as artistic director to create his own brand with backing from LVMH‘s Bernard Arnault would “not be a bad idea” as the group owned many old labels.


“Perhaps Nicolas wants to have his own label, which is not a bad idea,” Lagerfeld told Reuters in an interview on Thursday.













“And it would not be a bad idea if somebody such as Bernard Arnault would invest in a new label because there are so many old labels (within the LVMH group),” Lagerfeld said about the chief executive of the world’s biggest luxury group.


PPR, the French group which owns Balenciaga, shocked the fashion world by announcing this week the departure of Ghesquiere, who had been with the brand since 1997 and was the main architect of its revival.


The International Herald Tribune reported this week that one option for Ghesquiere was to create his own brand with the backing of Arnault, who controls LVMH, the world’s biggest luxury group, which owns many fashion brands including Louis Vuitton, Fendi and Celine.


Founded by Cristobal Balenciaga in 1919, his eponymous brand thrived until the late 1960s and then lay dormant until Ghesquiere took over as designer. The brand started to expand worldwide after PPR acquired it in 2001.


Balenciaga did not explain Ghesquiere’s departure clearly when it made the announcement on Monday but it suggested the designer was longing for a new creative adventure.


Lagerfeld, who runs his own brand on top of working as artistic director for LVMH’s Fendi and for privately owned Chanel, said he could not think about the succession.


“We (my team and I) only think in terms of one collection after the next collection,” he said. “In fashion, I am very much against projection in the far away future.”


Lagerfeld was speaking at the opening of an exhibition at the Grand Palais in Paris of his photos of celebrities themed around Chanel’s “little black jacket,” who were styled by Carine Roitfeld, former editor of the French Vogue.


The celebrities include artist Yoko Ono, John Lennon’s widow, film maker Sofia Coppola and actresses Kirsten Dunst and Milla Jojovich.


“I am happy I can do both fashion and photography because there is a link between the two but it is a link which I refuse to analyze,” Lagerfeld said.


PAVLOVSKY


Also present at the exhibition’s opening was Bruno Pavlovsky, president of Chanel’s fashion division, who like Lagerfeld would not be drawn too long on the subject of the designer’s succession.


“Karl is in great shape, I work every day with him and I can assure you that he is doing very well,” Pavlovsky said, adding that relations between Chanel and him had always been excellent.


“Of course one day there will be an after-Karl but Karl will have made Chanel so strong, with such strong codes that Chanel will find solutions,” Pavlovsky said.


The executive said Chanel, owned by the Wertheimer family, was doing well overall and expected 2012 to be another “good year” in spite of the global downturn which has affected many of its rivals including LVMH, Burberry and Gucci owner PPR.


However, he said the Chinese market was becoming more mature with growth levels in big cities such as Shanghai or Beijing becoming similar to that of European capitals or New York where Chanel has been for decades.


“We are no longer in the 20-30 percent growth levels we had seen (in previous years in China),” he said. “It can be more than 10 percent,” he said, referring to growth levels in big European cities.


Pavlovsky said Chanel planned to finish the year with 10 boutiques in China and 182 globally.


(Reporting by Astrid Wendlandt; Editing by Phil Berlowitz)


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