Facebook’s SnapChat-Style Sexting App Is Called Poke (Seriously)






Oh, well would you look at Facebook, trying to make a Christmas funny with its SnapChat copycat app. It’s called Poke! Get it? Because SnapChat is what the kids are all using for their sexting these days, apparently, and Poke — you know, that once kinda flirty Facebook future that’s now pretty much useless — can kind of do the same thing, and it kind of sounds like some bad sexual pun, too! Funny, Facebook, very funny, and way to admit the dirty little truth behind “poking” that we knew all along.


RELATED: Facebook to Launch Its Own SnapChat as Social-Network Clone Wars Live on






Oh, wait. They’re serious? Oh, yeah: Friday afternoon Facebook released Poke, its rumored iPhone app for the incredible vanishing half-message “that makes it fun and easy to say hello to friends wherever you are.” But don’t get too heavy on the old-school “Poke” comparisons, because the new app can actually send regular messages, photos, or videos, too — but only for short periods of time, because that is apparently what the kids like doing these days, if SnapChat’s huge success is any indication. There’s more of a time-bomb component to Poke, though: users can choose how long someone sees a poke before it ceases to exist forever — so you could sext poke all day long, because that, too, is apparently what the kids like doing these days, if SnapChat’s huge, smashing, sexy success is any indication.


RELATED: The Life and Philosophy of Mark Zuckerberg


Why would anyone use Poke over SnapChat? Well, the Facebook app itself has a much smoother interface than SnapChat, and you can report people behaving badly, and everyone’s already on Facebook, right? Maybe this is the breaking point Justin Bieber could never hit, when something sexy goes from the tween set to actual human beings. We’ll let you know when Poke shows up in our iPhone’s App Store; for now we’re not entirely sure if this is just some bad joke. (Although it is in the iTunes Store, so… we’ll see?)


Social Media News Headlines – Yahoo! News





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UK’s Kate and William to spend Christmas Day with her parents






LONDON (Reuters) – Britain’s Prince William and his pregnant wife Kate will spend Christmas Day with her parents, their office said on Saturday, in a break with the tradition of royals joining Queen Elizabeth at her country estate at Sandringham.


The Duke and Duchess of Cambridge will celebrate in private with Carole and Michael Middleton at their home in the village of Bucklebury, about 50 miles west of London.






“The Duke and Duchess of Cambridge will spend Christmas Day privately with the Middleton family,” a St James’s Palace spokesman said.


The couple’s decision was taken with the approval of the Queen. They are expected to visit Sandringham, in eastern England, for part of the Christmas holiday.


Kate, 30, who married the second-in-line to the throne in April 2011, spent four days in hospital this month with an acute form of morning sickness.


Members of the British royal family usually spend Christmas at Sandringham and stay until February, following a custom set by Queen Elizabeth’s father and grandfather. Kate and William spent Christmas there last year, meeting scores of wellwishers.


The Middletons are likely to join millions of Britons in watching Queen Elizabeth’s annual Christmas broadcast, a tradition that her grandfather George V started in 1932.


For the first time, the monarch has recorded her television broadcast in 3D. It will be shown at 1500 GMT on December 25.


(Reporting by Peter Griffiths; Editing by Kevin Liffey)


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Violence, fear & suspicion imperil Pakistan’s war on polio






ISLAMABAD, Pakistan (Reuters) – Pakistani health worker Bushra Bibi spent eight years trekking to remote villages, carefully dripping polio vaccine into toddlers’ pursed mouths to protect them from the crippling disease.


Now the 35-year-old mother is too scared to go to work after masked men on motorbikes gunned down nine of her fellow health workers in a string of attacks this week.






“I have seen so much pain in the eyes of mothers whose children have been infected. So I have never seen this as just a job. It is my passion,” she said. “But I also have a family to look after … Things have never been this bad.”


After the deaths, the United Nations put its workers on lockdown. Immunizations by the Pakistani government continued in parts of the country. But the violence raised fresh questions over stability in the South Asian nation.


Pakistan’s Taliban insurgency, convinced that the anti-polio drive is just another Western plot against Muslims, has long threatened action against anyone taking part in it.


The militant group’s hostility deepened after it emerged that the CIA – with the help of a Pakistani doctor – had used a vaccination campaign to spy on Osama bin Laden’s compound before he was killed by U.S. special forces in a Pakistan town last year.


Critics say the attacks on the health workers are a prime example of the government’s failure to formulate a decisive policy on tackling militancy, despite pressure from key ally the United States, the source of billions of dollars in aid.


For years, authorities were aware that Taliban commanders had broadcast claims that the vaccination drive was actually a plot to sterilize Muslims.


That may seem absurd to the West, but in Pakistan such assertions are plausible to some. Years of secrecy during military dictatorships, frequent political upheaval during civilian rule and a poor public education system mean conspiracy theories run wild.


“Ever since they began to give these polio drops, children are reaching maturity a lot earlier, especially girls. Now 12 to 13-year-old girls are becoming women. This causes indecency in society,” said 45-year-old Mir Alam Khan, a carpet seller in the northern town of Dera Ismail Khan.


The father of four didn’t allow any of his children to receive vaccinations.


“Why doesn’t the United States give free cures for other illnesses? Why only polio? There has to be an agenda,” he said.


While health workers risk attacks by militants, growing suspicions from ordinary Pakistanis are lowering their morale. Fatima, a health worker in the northwestern city of Peshawar, said that reaction to news of the CIA polio campaign was so severe that many of her colleagues quit.


“People’s attitudes have changed. You will not believe how even the most educated and well-to-do people will turn us away, calling us U.S. spies and un-Islamic,” said the 25-year-old who did not give her last name for fear of reprisals.


“Boys call us names, they say we are ‘indecent women’.”


Pakistan’s government has tried to shatter the myths that can undermine even the best-intentioned health projects by turning to moderate clerics and urging them to issue religious rulings supporting the anti-polio efforts.


Tahir Ashrafi, head of the All Pakistan Ulema Council, said the alliance of clerics had done its part, and it was up to the government to come to the rescue of aid workers.


“Clerics can only give fatwas and will continue to come together and condemn such acts,” he said. “What good are fatwas if the government doesn’t provide security?”


RISK OF POLIO RETURNING


That may be a tall order in Pakistan, where critics allege government officials are too busy lining their pockets or locked in power struggles to protect its citizens, even children vulnerable to diseases that can cripple or disfigure them.


Pakistani leaders deny such accusations.


Politicians also have a questionable track record when it comes to dealing with all the other troubles afflicting nuclear-armed Pakistan.


The villages where health workers once spent time tending to children often lack basic services, clinics, clean water and jobs. Industries that could strengthen the fragile economy are hobbled by chronic power cuts.


Deepening frustrations with those issues often encourage Pakistanis to give up on the state and join the Taliban.


So far it’s unclear who is behind the shootings. The main Taliban spokesman said they were opposed to the vaccination scheme but the group distanced itself from the attacks.


But another Taliban spokesman in South Waziristan said their fighters were behind an attack on a polio team in the northwestern town of Lakki Marwat on Monday. “The vaccinations were part of “a secret Jewish-American agenda to poison Pakistanis”, he said.


What is clear is the stakes are high.


Any gaps in the program endanger hard-won gains against a disease that can cause death or paralysis within hours.


A global effort costing billions of dollars eradicated polio from every country except Nigeria, Afghanistan and Pakistan.


Vaccinations cut Pakistan‘s polio cases from 20,000 in 1994 to 56 in 2012 and the disease seemed isolated in a pocket in the north. But polio is spread person-to-person, so any outbreak risks re-infecting communities cleared of the disease.


Last year, a strain from Pakistan spread northeast and caused the first outbreak in neighboring China since 1999.


Oliver Rosenbauer, a spokesman for the World Health Organization, said the group had been coming closer to eradicating the disease.


“For the first time, the virus had been geographically cornered,” he said. “We don’t want to lose the gains that had been made … Any suspension of activities gives the virus a new foothold and the potential to come roaring back and paralyze more children.”


MOURNING FAMILIES


Condemnation of the killings has been nearly universal. Clerics called for demonstrations to support health workers, the government has promised compensation for the deaths and police have vowed to provide more protection.


For women like Fehmida Shah, it’s already too late. The 44-year-old health worker lived with her family in a two-room house before gunmen shot her on Tuesday.


Her husband, Syed Riaz Shah, said she spent her tiny salary – the equivalent of just $ 2 a day – on presents for their four daughters. Even though the family was struggling, she always found some spare money for any neighbor in need.


“She was very kind and big hearted. All the women in our lane knew her,” he said.


“The entire neighborhood is in shock. Pray for my daughters. I will get through this. But I don’t know how they will.”


(Additional reporting by Imtiaz Shah in Karachi, Jibran Ahmad in Peshawar, Saud Mehsud in Dera Ismail Khan and Katharine Houreld in Islamabad; Editing by Michael Georgy and Sanjeev Miglani)


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The Hedge Fund Hunger Games






The first idea that Tim Harrington, Brian Tomeo, and Spencer Deering had for a business was to gather up brand-new hedge funds and nurture them. They’d invite them to make use of their office in Miami Beach, where they could get advice, legal help, expensive software, and eventually an introduction to investors, with the three benefactors collecting a fee. The second idea, the one the trio went with, was the exact opposite. They would assemble the hedge funds and make them fight.


1b7e6  investing hedgefundhunger52  02  inline202 The Hedge Fund Hunger GamesGrant Cornett for Bloomberg BusinessweekHarrington got into hedge funds in college






This was back in April. The three had been introduced by mutual friends and colleagues over the years: Harrington, a 37-year-old with prematurely white hair who’d gone straight into hedge funds out of college, met Tomeo, 40, a broken-nosed former Princeton lacrosse champion, at a party not long after the latter left JPMorgan Chase (JPM) as a managing director in 2007. Deering, 37, had come late to finance after first working as a teacher and writer; he had promise as a model-handsome charmer of wealthy investors. Together they sensed there was money in the nascent Miami hedge fund scene. Much like investing in a young tech company, hooking up a new hedge fund with seed capital—including, perhaps, some of their own—can be lucrative. The problem was that Harrington and his partners couldn’t tell which of the new funds asking for their money were any good.


It wasn’t easy for the aspiring hedge fund managers they were talking to, either. Investors won’t give capital to managers who have no experience, but managers can’t get experience without capital. Most fledgling funds try to get past this paradox by offering back-tested results, modeling how their trading algorithms would have performed in years past. This is basically historical fiction, and it ignores a fundamental truth of investing: What happened yesterday doesn’t predict what the market will do tomorrow.


What matters is actual performance, which is how Tomeo and Harrington came up with the idea to run a tournament to fill their incubator, weeding out pretenders by making managers compete in real time with real money. The finisher who made the most while risking the least would win the right to manage seven figures of capital. They called their company Battle-Fin.


1b7e6  investing hedgefundhunger52  01  inline202 The Hedge Fund Hunger GamesGrant Cornett for Bloomberg Businessweek“The system is completely broken,” says Tomeo


A trial tournament in July proved that the mechanics of the concept worked. It also demonstrated how difficult it was to win: Tomeo entered and finished fifth out of six. For the next tournament, which they considered their real debut, the three men secured $ 10 million in money to manage from a capital provider in New York named Liquid Holdings Group. Winners would be chosen in three divisions. The “elite” category was for managers who were already running other people’s money. The winner here would run $ 5 million of the prize capital. The “professional” division was for entrants risking any amount of their own money. The winner would run $ 3 million. And the “launch” division was for contestants trading only on paper. There would be two winners in this division, each to be allocated $ 1 million.


Battle-Fin restricted the tournament to quants—managers who develop computer-run algorithms that set rules for trading. Quants aren’t new to Wall Street by any means, but if you’re looking for innovative ideas, then computational finance isn’t a bad place to start. And hedge funds badly need new blood. With notable exceptions, they’ve been clobbered by the plain-old stock market in the last four years. In 2012, the average hedge fund has returned 3 percent; the Standard & Poor’s 500-stock index has returned 15 percent. Investors, meanwhile, pay dearly for the privilege of underperforming—managers typically keep 20 percent of any profit, plus a 2 percent management fee.


“We want to find great people, help them build their business, and build a great business on our own,” Harrington says. “If that turns the hedge fund industry on its head, that’s not our worry.”
 
 
In August, Alon Bochman was sitting at the desk he rents at an office near Grand Central Terminal in New York, reading posts in a LinkedIn (LNKD) group for emerging managers, when he came across one from Harrington. “Our real-time, real-capital tournaments democratically and objectively identify tomorrow’s best and brightest computational financiers—wherever they might be,” it read. A few clicks and an e-mail exchange later, Bochman was in the tournament.


Two and a half years ago, Bochman was earning a comfortable six figures as a portfolio manager at SC Fundamental, a New York hedge fund notable for launching the careers of a handful of wildly successful managers, including David Einhorn. One day he noticed an anomaly in the way a certain kind of exchange-traded fund behaved, so he devised a trading strategy for his personal account that wouldn’t require a lot of monitoring. “I never really looked at it. I had a full-time job I liked very much,” he says. “Then, around December, I got a statement from my broker. And I was like, Huh.” Bochman’s returns had passed 30 percent a year. In March he quit to start his own fund.


Even with his connections, Bochman, 39, found it tough to get a piece of the money streaming into billion-dollar funds. He knew that, as in any industry, pitching hedge fund investors meant hearing “no” a lot. What he wasn’t prepared for were the questionnaires from due diligence firms, the industry’s post-Madoff gatekeepers, which struck him as both invasive and superficial. Asking about strategy and risk tolerance made sense. But his heart condition? Whether he was in the midst of a divorce?


Of every dollar flowing into the industry, 96¢ go to the biggest hedge funds, those with more than $ 5 billion under management. For upstarts, getting capitalized usually means hitting up friends and family, then approaching professional contacts, and gradually moving upward. Performance is the most important factor for attracting money, but allocations are often won or lost on the margins of personality—knowing the right people, having impressive literature, nailing the interview. “The hedge fund industry is supposed to be merit-based, and it’s supposed to be entrepreneurial,” says Bochman. “I think that people have been so shell-shocked by the financial crisis and Bernie Madoff that they’ve given up on merit. They’ll settle on a checklist that ensures you belong to certain clubs, know the right people.” He found the tournament concept refreshing. “What they’re doing is important. They’re one of the few guys saying, ‘This is a contest of ideas, and may the best strategy win.’ This is something that our industry really, really needs.”


Bochman was one of about 3,000 visitors to Battle-Fin’s website after Harrington and Deering began promoting it, which in the small world of aspiring quant hedge fund managers is a lot. About 130 applied.


1b7e6  investing hedgefundhunger52  03  inline202 The Hedge Fund Hunger GamesGrant Cornett for Bloomberg BusinessweekDeering once taught English and wrote a novel


“The pedigree of the guys who are coming across our screen—it’s crazy,” says Deering. (One of the two finalists in the trial tournament was a group of Massachusetts Institute of Technology Ph.D.’s.) “The fact that these guys are coming to us, in these little tournaments that we’re running? It’s so evident that the system is cocked up.”


The funds chosen—26 in all—were run by a motley bunch. Two master-level chess players headed one, which they called Chessica, after the original name, Genius Hedge Fund, failed to go over well with investors. Another fund, ProForza Advisors, boasted a rocket scientist who had worked for NASA, studying weather in the magnetosphere. Yet another contender, Stephen Longo, a Fu Manchu–mustache-sporting Long Islander, had spent 20 years as an engineer at General Motors (GM). He had been racking up impressive gains on a theoretical trading platform for years, making millions, but only on paper; winning the tournament would give him a chance to prove his investing chops without a safety net. Martin Rosenburgh, who managed $ 1 million of friends-and-family money from home on a 27-inch iMac, was also optimistic. Should he win, he hoped to focus on his fund full time. “It’s like American Idol for quant strategies,” he says.


Several contestants spoke of the difficulty of getting in the room with potential investors. “We’re extremely good at the statistical analysis and data visualization and so forth,” says Mark Maldonis, 48. “But marketing skills? God was not good to me.”


Trading began on Oct. 1. From their offices in New York, Los Angeles, London, and elsewhere, the contestants tracked each other’s gains on a leader board updated daily at battle-fin.com. The launch category, where the gains or losses were all on paper, was naturally the most volatile. Longo was up 10 percent after just seven days, with a strategy that took its cues from volatility in the S&P 500. In the $ 5 million elite category—where the contestants were managing real money belonging to real clients—the range was much tighter, within a point or two of zero. Two weeks in, with the stock market down, even flat returns could be regarded as an accomplishment.


Perhaps the most impressive performance was in the intermediate division, where the managers’ own money was at stake. Rosenburgh, 45, had gained nearly 4 percent by the end of October, but he was quickly left in the dust by the 10 percent returns of a fund manager listed on the tournament scoreboard as Z. Liu. Nobody could dig up much information on him, but with a strategy built on the statistical analysis of historical trading data, he seemed proof that the Battle-Fin tournament might be able to pick managers better than Wall Street.
 
 
Dealing with startups often means forgiving a certain amount of amateur behavior. As the contestants entered the second month, several realized something: Battle-Fin was just as much a startup as they were.


Harrington handled the tournament’s day-to-day operations—checking in with contestants, putting out fires, and generally behaving like a theater manager on opening night. Tomeo was the high-level strategist. Deering was in charge of marketing. They had put the tournament concept into practice as rapidly as they could after inventing it. This meant hiccups, corner-cutting, and a lot of improvisation.


1b7e6  investing hedgefundhunger52  04  inline405 The Hedge Fund Hunger Games


John LaChance, a former vice president at JPMorgan, logged on to battle-fin.com one day to discover an organization called “LaChance Capital” next to his name. “There’s no such thing,” he says with a laugh. “I guess they just put that down. I don’t think I’d name it that, either.” Several competitors noticed that five funds disappeared from the leader board without explanation. The head of ProForza Advisors, Sunil Pai, hadn’t even signed up to enter the tournament. One day over the summer, he says, he had called Harrington to learn more about the contest after seeing a LinkedIn post. The next thing he knew, ProForza was listed in the elite category. Harrington “entered us into the competition. I hadn’t actually applied for it,” says Pai, 49.


Midway through the tournament, even some high-level decisions had been left up in the air. “It’s definitely a work in progress,” Harrington says. Who was Battle-Fin’s chief executive officer, anyway? “I don’t know,” Tomeo says. “Who do you think it is?”


All three founders were concerned that two months was too short for a tournament and that they’d end up crowning the merely lucky. The partners also hadn’t figured out how to split revenue on the fees they’d collect from connecting the tournament winners to the capital providers. “One, we trust each other, and two, we’re not fighting over future spoils that haven’t even appeared yet,” Harrington says. “I’ve seen so many businesses where people are fighting and clawing for percentages that never even end up working out.”


There are no signs of tension among the three—the reverse, actually, thanks mostly to Deering’s nonstop comedy routine. A college lacrosse player like Tomeo, Deering taught English at a Chicago-area high school after graduating and self-published a novel about a man, a motorcycle, and the West. Today, he may be the only man in hedge funds who’s written about Southern food for Esquire and relationships, under a pen name, for Cosmopolitan. (“If you’re feeling the love itch, chances are he is as well but is too chicken to be the initiator.”) A theater director in Charleston, S.C., where he lives, nicknamed him Johnny Touchdown.


Harrington had traced a semi-charmed path through the hedge fund world. He started with an internship in college; skipping the usual period of apprenticeship at an investment bank, Harrington then bounced from one billion-dollar operation to the next—Galleon Group, SAC Capital Advisors, JPMorgan. (At the moment, two of those firms are known for scandal: Galleon’s founder, Raj Rajaratnam, was convicted in 2011 of securities fraud, and SAC, headed by Steven Cohen, is the subject of a federal investigation into insider trading. Harrington declined to discuss the topic.) He left JPMorgan in 2009 to start his own business, a hedge fund seeder called Lion’s Path Capital, which is tied to Battle-Fin in several ways. It staked the $ 1 million prize for the company’s trial tournament, and winners use Lion’s Path’s trading platform to manage the capital they win access to.


In Miami Beach, where the finance scene is tiny, Battle-Fin rents office space from Ray Langston, a hedge fund manager who’s a generation older and represents the success the trio hope to have and the old guard they mean to destroy. Langston collects Ferraris, drives away from lunch in a $ 440,000 Porsche Carrera GT roadster, and doesn’t care what you make of his calling President Obama a socialist. Hedgies of Langston’s era had the good fortune to trade amid a decades-long bull market. Back in Battle-Fin’s conference room, Tomeo says the managers in his tournament, with their computational skills, would eat Langston alive. “I just say, Hey, Ray, I would love to see you make it today,” says Tomeo. “I’d love to put you against these guys that I find.”
 
 
The contestants were putting up strong numbers. In the tournament’s final days, 8 out of 10 funds in the real-money divisions were beating the S&P.


LaChance, 37, lives in Pittstown, N.J.—horse country—in a 5,100-square-foot house with a three-car garage on two acres that he bought in 2006, at the absolute top of the market. It’s beautiful, an hour and 40 minutes from New York, and the school bus picks up his twin 12-year-old boys right at the curb. The Tuesday after Thanksgiving, a wet snow is falling, and LaChance misses nothing about his old commute, back when he was a JPMorgan trader. Wearing a North Face fleece and socks, he walks into his ground-floor home office, equipped with three widescreen monitors tracking $ 2.5 million of friends-and-family money in his portfolio. He is up 4 percent in the tournament’s top category—too high for anyone to catch up. For him, winning will be anticlimactic. Harrington has already had him record a victory video.


LaChance runs a handful of strategies at any given time. He mostly trades ADRs—American depositary receipts, or securities of foreign companies that trade on U.S. markets—that he believes are mispriced. LaChance says it’s profitable but not very scalable. “On some of these things, I’m literally the only person trading it,” he says.


In the 12 months leading up to the tournament, LaChance’s return was 39.9 percent. If he repeats that performance in 2013, with $ 5 million in Battle-Fin money in his portfolio, he stands to make an extra $ 399,000 in fee income. If his strategy goes bust, he’ll make nothing: Hedge funds ordinarily charge a 2 percent fee on their assets under management, which guarantees them revenue even in a down year, but Battle-Fin’s rules restrict winners from doing this.


For Longo, 54, winning is more surreal. The former General Motors engineer held on to his early lead in the launch category, giving the paper trader $ 1 million in real capital to invest. “I’m slightly speechless,” he says. “It’s kind of a double-edged sword. I’m obviously happy that I won. The other side is that now the real competition starts, with the markets.” Longo is truly speechless when a reporter points out something Battle-Fin had never told him: They’d be keeping the first 5 percent of any gains he made on the $ 1 million, in exchange for taking a risk on a total unknown. The asterisk applies only to his category. After recovering, Longo says there’s no hard feelings. “There might be a few misunderstandings or a few things that are unclear at this point, but again, the opportunity still far outweighs any of that,” he says.


Rosenburgh fared better under Battle-Fin’s make-it-up-as-we-go-along approach. He never climbed out of second place in the intermediate division but was thrilled to discover that he’d won something anyway. Battle-Fin had decided not to name two winners in the launch division after all, in favor of a floating $ 1 million “wild card.” In late November, Rosenburgh joined the other winners at the Lion’s Path offices in Manhattan, grinning in a group photo with Harrington.


Afterward, the victors walked to a nearby bar. Among them: the mysterious Z. (Zongjian) Liu. He had posted an astonishing 14 percent return in just two months in the intermediate division, risking his own money. As Liu began to explain his strategy and his background, it quickly became clear that he had not thought through the implications of winning $ 3 million to manage—or even competing in the tournament in the first place.


Liu, 34, has a full-time job at a major bank. Every bank’s rules are different about what employees are allowed to do with their investments, but publicly traded, highly regulated banks generally want to know if their employees are running hedge funds in their spare time. Liu hadn’t cleared his participation in the tournament with the compliance department. “Ideally, I should not do this,” he says in nearly perfect English. “Because there will be conflict of interest. Although in my case, there is no conflict of interest.” In two months, Liu says, he will probably quit to manage his portfolio full time. His plan is simply to not let the bank’s compliance officers find out.


Before the tournament, Liu says, he ran about $ 390,000 in friends-and-family money. If he keeps up his annualized 2012 rate of 43.6 percent next year, performance fees on $ 3 million in Battle-Fin money would run to $ 295,608. That may be more than his bank salary, but Liu would also be taking on a huge personal risk. If his models stop working as well and he merely matches the industry’s average 2012 return of 2.9 percent, performance fees on that $ 3 million would total only $ 17,400. Before expenses and taxes.


On the last day of the tournament, Nov. 30, Harrington is unsure how the man he has entrusted with $ 3 million is handling the situation. “We say to people, ‘Look, you have to get clearance from your employer to see if there’s any conflict of interest.’ His whole thing is he said he plans to quit. So, I mean, it’s a little—that’s the one that I don’t know how …” Harrington doesn’t finish the thought.


There are grander plans to discuss. Harrington has just come from a meeting with an investor who’s considering fronting as much as $ 50 million for a third tournament. At the same time, the trio want to take the concept beyond quant trading strategies to commodities, currencies, real estate. “The whole asset management industry is ripe for a technology that turns it upside down,” says Tomeo. Of course, they also want to go global. “We’re going to do Battle-Fin Latin America,” Harrington says. “We’re going to do Battle-Fin Canada. We’re going to do Battle-Fin Asia and Battle-Fin Global, which is when we’re going to take all of the winners and bring them to Miami for kind of a conference and showcase them to different people.”


A few days later, Harrington e-mails to say he’s hopeful the company will win a patent on the tournament. “Things are really moving fast,” he writes. Below his signature is a new Battle-Fin slogan: Time to sink or swim.


Businessweek.com — Top News





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Canada spending growth sluggish in November, Mastercard says






(Reuters) – Canada‘s holiday shopping season got off to a slow start in November with retail sales rising only 1.3 percent from the previous year, compared with 4.2 percent growth a year earlier, according to data released by MasterCard on Thursday.


Still, the shopping season was still young in November. MasterCard Advisors, the payment company’s research and consulting division, found that in recent years, holiday shopping peaks from December 20 to December 22.






“Many Canadians may have gotten an early start with Black Friday and Cyber Monday this year, but it’s still a very young phenomenon in Canada,” Senior Vice-President Richard McLaughlin, said in a release.


The Friday after U.S. Thanksgiving is the unofficial start to the holiday shopping season south of the border, and in recent years retailers have imported Black Friday sales to Canada.


Some also promote online sales the following Monday.


Canada’s online retail sales continued to grow in November, increasing 26.4 percent.


(Reporting by Allison Martell; Editing by Peter Galloway)


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Google working on “X Phone”, “X” tablet to take on rivals – WSJ






(Reuters) – Google Inc is working with recently acquired Motorola on a handset codenamed “X-phone”, aimed at grabbing market share from Apple Inc and Samsung Electronics Co Ltd, the Wall Street Journal said, citing people familiar with the matter.


Google acquired Motorola in May for $ 12.5 billion to bolster its patent portfolio as its Android mobile operating system competes with rivals such as Apple and Samsung.






The Journal quoted the people saying that Motorola is working on two fronts: devices that will be sold by carrier partner Verizon Wireless, and on the X phone.


Motorola plans to enhance the X Phone with its recent acquisition of Viewdle, an imaging and gesture-recognition software developer. The new handset is due out sometime next year, the business daily said, citing a person familiar with the plans.


Motorola is also expected to work on an “X” tablet after the phone. Google Chief Executive Larry Page is said to have promised a significant marketing budget for the unit, the newspaper said quoting the persons.


Google was not immediately reachable for comments outside regular U.S. business hours.


(Reporting by Balaji Sridharan in Bangalore; Editing by Richard Chang)


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‘Skyfall’ Will Open January 21 in China, Won’t Face ‘Hobbit’






LOS ANGELES (TheWrap.com) – Global blockbuster “Skyfall” will open on January 21 in China, a person with knowledge of the situation confirmed to TheWrap Friday.


A strong run in China will be critical if “Skyfall” is to hit $ 1 billion at the worldwide box office.






The date means that Sony and MGM’s newest 007 film will likely roll out ahead of Warner Bros.‘ Middle-earth epic “The Hobbit,” which is expected to open in February, after China’s February 9 Golden Week holidays are under way.


Chinese officials have aggressively protected their domestic film industry this year, in some case by slotting major U.S. films against each other to reduce their box-office impact.


The studios had been waiting for confirmation from on a release date since opening the 23rd James Bond thriller in the U.K. on October 26.


The two studios had been in a similar situation with two box-office hits earlier this year, when “Dark Knight Rises” and “The Amazing Spider-Man” both opened on August 27. That cut their grosses, but China still became the No. 1 foreign market for both films, with “Dark Knight Rises” taking in $ 52 million for Warner Bros. and “Spider-Man” taking in $ 48 million for Sony.


“Skyfall,” which stars Daniel Craig, has a good shot at becoming the first Bond movie to hit the billion-dollar mark at the box office. But it will need strong performances in China and Japan where it has taken in more than $ 16.7 million since opening three weeks ago – to get there.


The film has made more at the box office than any of the 22 previous James Bond films, with $ 953 million globally since opening on October 26. The majority of that – $ 678 million – has come from overseas. The top market is the U.K., where “Skyfall” is that country’s biggest movie ever with more than $ 158 million.


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Ky. court upholds decision in penis removal case






LOUISVILLE, Ky. (AP) — A Kentucky man lost his bid Friday to force a doctor to pay damages for removing a cancer-riddled section of his penis during what was scheduled to be a simple circumcision.


The Kentucky Court of Appeals found that a jury correctly concluded that 66-year-old Phillip Seaton of Waddy consented to allow Dr. John Patterson to perform any procedure deemed necessary during the Oct. 19, 2007, surgery.






Patterson, a Kentucky-based urologist, maintains he found cancer in the man’s penis during surgery and that it had to be removed. The patient claims the surgery was supposed to be a circumcision and he never authorized the amputation, nor was he given a chance to seek a second opinion.


“Additionally, there is uncontroverted testimony in the record that if Mr. Seaton were not treated for the penile cancer, it would prove fatal in the future,” Judge Janet Stumbo wrote for the court.


Judge Michael Caperton dissented, but did not issue a written opinion.


Clay Robinson, a Lexington-based attorney for Patterson, said the opinion was “very well-reasoned” and fact-based.


“You always appreciate when you see judges at any level go into that amount of detail,” Robinson said.


Seaton and his wife, Deborah, sued Patterson, a Kentucky-based urologist, in Shelby County Circuit Court in 2008. Seaton, now in his 60s, was having the procedure to better treat inflammation. The Seatons also sued Jewish Hospital, where the surgery took place. The hospital settled with the couple for an undisclosed amount.


Both sides agree that Seaton had squamous cell carcinoma, a type of skin cancer, in his penis. Patterson concluded that a tumor had overtaken much of the top of the organ, which made it impossible to insert a catheter.


“He also opined that serious complications and additional surgery could result if he did not insert the catheter,” Stumbo wrote.


The main point of contention is whether Patterson acted reasonably in removing the organ immediately or if amputation could have been delayed to let Seaton seek other medical options.


Stumbo and Judge Donna Dixon concluded that, even though Seaton had limited ability to read and write, he never informed the doctor of that fact and signed the consent form in the presence of a witness. The Seatons claimed that the waiver didn’t give Patterson authority to conduct an amputation without further consent.


“They maintain that no harm would have resulted if Dr. Patterson has consulted with either of them before proceeding, or if he had allowed them to consult with another physician to get a second opinion or other treatment options,” Stumbo wrote.


Stumbo wrote that Patterson acted properly because the tumor had consumed such a large section of the organ.


“For this reason alone, the resection of the tumor was ‘necessary and proper’ in the context of inserting a catheter,” Stumbo wrote.


Kevin George of Louisville, the attorney for Seaton, did not immediately return messages seeking comment.


______


Follow Associated Press reporter Brett Barrouquere on Twitter: http://twitter.com/BBarrouquereAP


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The Year’s Best & Worst Investments






Winners
Best International Stock (+283%): India consumes more than $ 20 billion worth of whiskey each year—the most in the world—and United Spirits (UNSP) is the nation’s largest distiller. The company’s sales doubled in four years. The United Kingdom’s Diageo (DEO) bought a controlling stake in United Spirits in November.
 
1f6ae  inv bestworst2 202 The Years Best & Worst InvestmentsBest U.S. Large-Cap Stock (+224%): The good news for Regeneron Pharmaceuticals (REGN) shareholders included strong sales for a treatment for eye diseases. Total revenue jumped fourfold last quarter. The Tarrytown (N.Y.)-based company also won approval for a chemotherapy drug and is developing treatments for rheumatoid arthritis and high cholesterol.
 
Best Bond Fund (+26%): The GMO Emerging Country Debt Fund (GMCDX) invests in debt issued by emerging-market countries, a strategy that’s worked in nine of the last 10 years. Its top holding is Venezuelan bonds, a sign that its managers are willing to take risks in particularly unstable countries.
 
1f6ae  inv bestworst3 202 The Years Best & Worst InvestmentsBest Initial Public Offering (+105%): Retailer Five Below (FIVE) sells candy, stationery, and beauty products priced at $ 5 or less and aimed at teenagers. Sales are growing 47 percent a year.
 
Best Equity Mutual Fund (+39%): The Fidelity Select Biotechnology Portfolio (FBIOX) spreads $ 2.7 billion in assets over 131 biotechnology stocks. A top holding: Gilead Sciences (GILD), the California-based biopharmaceutical company.
 
1f6ae  inv bestworst4 2021 The Years Best & Worst InvestmentsBest Commodity (+24%): Wheat prices rose in 2012 as drought cut into supply from the grain belts of Russia, Australia, and the U.S. Wheat is a $ 14.4 billion crop in the U.S., where it ranks fourth behind corn, soybeans, and hay.
 
Best Exchange-Traded Fund (+77%): Signs of a housing recovery sent shares of homebuilders soaring this year, boosting the IShares Dow Jones U.S. Home Construction Index Fund (ITB).
 
Losers
Worst Exchange-Traded Fund (-79%): The ProShares VIX Short-Term Futures ETF (VIXY) holds futures contracts that are profitable when the VIX index, a measure of U.S. stock market volatility, rises. 2012 was a calm year.
 
1f6ae  inv bestworst7 202 The Years Best & Worst InvestmentsWorst Commodity (-35%): Abundant supply is depressing coffee prices. Brazil, the world’s largest grower, has almost doubled its output in the past decade, producing another record crop this year.
 
Worst Equity Mutual Fund (-17%): The Federated Prudent Bear Fund (BEARX) holds gold mining stocks and other investments it expects will do well in times of financial stress. That strategy suffers in years such as 2012, when stocks rise.
 
1f6ae  inv bestworst8 202 The Years Best & Worst InvestmentsWorst Initial Public Offering (-30%): Facebook (FB) plunged as much as 53 percent after its $ 16 billion debut in May. The stock rallied on news that third-quarter sales rose 32 percent, beating analysts’ estimates.
 
Worst Bond Fund (+.12%): While the GMO U.S. Treasury Fund (GUSTX) may just barely be holding its value at yearend, its extremely cautious strategy means returns aren’t keeping up with inflation. The fund is invested entirely in U.S. Treasury bills, government debt that matures in less than a year.
 
1f6ae  inv bestworst10 202 The Years Best & Worst InvestmentsWorst U.S. Large-Cap Stock (-43%): Hewlett-Packard’s (HPQ)annus horribilis was marked by a third-quarter loss that was its worst ever, including an $ 8 billion writedown related to the dwindling value of its enterprise services business. HP later took an $ 8.8 billion writedown related to accounting problems at Autonomy, a software maker it acquired last year. In September, HP announced plans for 29,000 job cuts.
 
Worst International Stock (-81%): The biggest target for the European Union’s bailout fund for Spanish banks, Bankia (BKIA), forecasts it will lose $ 25 billion in 2012. The bank, formed last year from the merger of seven regional savings banks damaged by Spain’s real estate downturn, is in the midst of cutting more than a quarter of its workforce.


Data compiled by Bloomberg from Dec. 31, 2011, to Dec. 17, 2012. Criteria – Bond Funds: 725 bond mutual funds based in the U.S. with assets of $ 500 million or more. Commodities: 18 global commodities tracked by Bloomberg. Equity Mutual Funds: 796 U.S.-based equity mutual funds with assets of $ 1 billion or more. Exchange-Traded Funds: 1,062 U.S.-based ETFs, excluding those that use leverage. Initial Public Offerings: 103 U.S. IPOs with an offer size of at least $ 100 million. International Stocks: The MSCI AC World Index. Large-Cap Stocks: 367 stocks on U.S. exchanges with market value of more than $ 10 billion.






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Italy PM Monti resigns, elections likely in February






ROME (Reuters) – Italian Prime Minister Mario Monti tendered his resignation to the president on Friday after 13 months in office, opening the way to a highly uncertain national election in February.


The former European commissioner, appointed to lead an unelected government to save Italy from financial crisis a year ago, has kept his own political plans a closely guarded secret but he has faced growing pressure to seek a second term.






President Giorgio Napolitano is expected to dissolve parliament in the next few days and has already indicated that the most likely date for the election is February 24.


In an unexpected move, Napolitano said he would hold consultations with political leaders from all the main parties on Saturday to discuss the next steps. In the meantime Monti will continue in a caretaker capacity.


European leaders including German Chancellor Angela Merkel and European Commission President Jose Manuel Barroso have called for Monti’s economic reform agenda to continue but Italy’s two main parties have said he should stay out of the race.


Monti, who handed in his resignation during a brief meeting at the presidential palace shortly after parliament approved his government’s 2013 budget, will hold a news conference on Sunday at which he is expected clarify his intentions.


Ordinary Italians are weary of repeated tax hikes and spending cuts and opinion polls offer little evidence that they are ready to give Monti a second term. A survey this week showed 61 percent saying he should not stand.


Whether he runs or not, his legacy will loom over an election which will be fought out over the painful measures he has introduced to try to rein in Italy’s huge public debt and revive its stagnant economy.


His resignation came a couple of months before the end of his term, after his technocrat government lost the support of Silvio Berlusconi‘s centre-right People of Freedom (PDL) party in parliament earlier this month.


Speculation is swirling over Monti’s next moves. These could include outlining policy recommendations, endorsing a centrist alliance committed to his reform agenda or even standing as a candidate in the election himself.


The centre-left Democratic Party (PD) has held a strong lead in the polls for months but a centrist alliance led by Monti could gain enough support in the Senate to force the PD to seek a coalition deal which could help shape the economic agenda.


BERLUSCONI IN WINGS


Senior figures from the alliance, including both the UDC party, which is close to the Roman Catholic Church, and a new group founded by Ferrari sports car chairman Luca di Montezemolo, have been hoping to gain Monti’s backing.


He has not said clearly whether he intends to run, but he has dropped heavy hints he will continue to push a reform agenda that has the backing of both Italy’s business community and its European partners.


The PD has promised to stick to the deficit reduction targets Monti has agreed with the European Union and says it will maintain the broad course he has set while putting more emphasis on reviving growth.


Berlusconi’s return to the political arena has added to the already considerable uncertainty about the centre-right’s intentions and increased the likelihood of a messy and potentially bitter election campaign.


The billionaire media tycoon has fluctuated between attacking the government’s “Germano-centric” austerity policies and promising to stand aside if Monti agrees to lead the centre right, but now appears to have settled on an anti-Monti line.


He has pledged to cut taxes and scrap a hated housing tax which Monti imposed. He has also sounded a stridently anti-German line which has at times echoed the tone of the populist 5-Star Movement headed by maverick comic Beppe Grillo.


The PD and the PDL, both of which supported Monti’s technocrat government in parliament, have made it clear they would not be happy if he ran against them and there have been foretastes of the kind of attacks he can expect.


Former centre-left prime minister Massimo D’Alema said in an interview last week that it would be “morally questionable” for Monti to run against the PD, which backed all of his reforms and which has pledged to maintain his pledges to European partners.


Berlusconi who has mounted an intensive media campaign in the past few days, echoed that criticism this week, saying Monti risked losing the credibility he has won over the past year and becoming a “little political figure”.


(Additional reporting by Gavin Jones, Massimiliano Di Giorgio and Paolo Biondi; Writing by Gavin Jones and James Mackenzie; Editing by Michael Roddy)


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Reacting to users’ outcry, Facebook’s Instagram reverts to prior policy on advertising






SAN FRANCISCO – Instagram has abandoned wording in its new terms-of-service agreement that sparked outcry from users concerned it meant their photos could appear in advertisements.


In a blog post late Thursday, the popular mobile photo-sharing service says it has reverted to language in the advertising section of its terms of service that appeared when it was launched in October 2010.






Instagram is now owned by Facebook Inc. and maintains that it would like to experiment with different forms of advertising to make money.


Its blog post says that it will now ask users’ permission to introduce possible ad products only after they are fully developed.


The outcry to the changes announced earlier this week led the company to clarify that it has no plans to put users’ photos in ads.


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Mission Impossible?: Can Tom Cruise Launch a Box-Office Franchise with ‘Jack Reacher’?






LOS ANGELES (TheWrap.com) – Paramount hopes it’s launching a franchise with “Jack Reacher,” the Tom Cruise action thriller that hits theaters Friday.


It will be tricky in a crowded holiday marketplace, and Cruise isn’t the box-office bonanza he once was. But one need only look back to last year’s “Mission: Impossible – Ghost Protocol” to see how it might work. That film opened to $ 12 million on December 16 and went on to make $ 209 million and nearly $ 700 million worldwide for Paramount.






Jack Reacher” will be in about 3,200 theaters, and it will have plenty of competition. Universal’s Judd Apatow comedy “This Is 40″ opens wide Friday, and Paramount‘s ‘Guilt Trip” and Disney’s 3D re-release of “Monsters Inc.” opened Wednesday.


A slew of limited releases, led by Kathryn Bigelow’s “Zero Dark Thirty,” along with this year’s winner of the Palme d’Or at Cannes “Amour,” and tsunami survival tale “The Impossible” are also competing for moviegoers’ attention, along with a number of holdover hits.


No movie, though, will come close to catching reigning box-office champ “The Hobbit: An Unexpected Journey,” which remains in more than 4,000 theaters. Peter Jackson’s latest Middle-earth epic will take in north of $ 40 million, industry analysts say, with “Jack Reacher” and “This Is 40″ battling for second with less than half of that.


Warner Bros.’ “Hobbit” has rolled to $ 106 million in the U.S. since opening to $ 85 million last weekend. Its international total – $ 188 million as of Thursday – is even bigger.


In “Jack Reacher,” Cruise plays an ex-military investigator; the film is based on bestselling author Lee Child’s novel “One Shot” and written for the screen and directed by Christopher McQuarrie. It’s from David Ellison’s Paramount-based Skydance Productions and was produced for about $ 60 million by Cruise, Don Granger, Paula Wagner and Gary Levinsohn.


Robert Duvall and Richard Jenkins co-star in the PG-13 crime thriller, which has a 53 percent positive rating at Movie Review Intelligence.


No is expecting “Jack Reacher” to match “MI:4″ at the box office. The Reacher novels have a following, but nowhere near that of the “Mission Impossible” franchise. Cruise’s recent box-office record has been uneven, and the film’s Facebook and Twitter activity is not particularly strong.


Jack Reacher” could wind up playing more like Cruise’s “Knight and Day,” which opened to $ 20 million and went on to make $ 76 million for Fox in 2010, or “Valkyrie,” which did $ 83 million in 2008 after opening to $ 21 million. Cruise was critically lauded for his foray earlier this year as an aging rock icon in the musical “Rock of Ages,” but that was one of the year’s bigger box-office duds.


Jack Reacher” should play strongly with action fans, but Cruise’s personal problems could limit its broader appeal.


“I can’t imagine his divorce from Katie Holmes and the custody battle hasn’t hurt him some with women,” BoxOffice.com vice president and chief analyst Phil Contrino told TheWrap Thursday. “Actions fans will come out, but going beyond that demographic is going to be tough for him.”


On the other hand, Universal says that it tracking suggests “This Is 40″ will do quite well with women — and women over 25 in particular.


“This Is 40,” is, as the marketing campaign points out, a “sort of sequel” to Apatow’s “Knocked Up,” which opened to $ 30 million and went on to make nearly $ 150 million five years ago. Like “This Is 40,” that one was written and directed by Apatow and starred Paul Rudd and Leslie Mann.


“40″ is the fourth film Apatow has directed, all for Universal (“Funny People” and “40-Year-Old Virgin” are the other two). The ensemble cast also features Albert Brooks, John Lithgow, Megan Fox, Maude Apatow, Iris Apatow, Chris O’Dowd, Jason Segel, Melissa McCarthy and Lena Dunham.


It’s R-rated and has a 62 percent positive rating at Movie Review Intelligence. The production budget was $ 35 million.


“This looks like the strongest comedy of the season,” Jeff Bock, senior analyst at Exhibitor Relations told TheWrap, “but it’s still a bit of a wild card. It’s going to connect with the New York and L.A. crowds; the key will be whether the Heartland audiences embrace it or see it as a little too hip. It will take time to tell, because of the season.”


Films released at this time of year tend to open lower because the marketplace is so crowded – by Friday, 11 new films will have hit opened this week – and the fact that many potential moviegoers are districted by shopping and other holiday preps. On the other hand, they often show lasting power and make up what they don’t take in on the weekend with stronger showings on the weekdays.


“Things could well come in lower than people are expecting across the board this weekend,” Bock said, “but look for many of these movies to make it up over the holidays.”


Summit will be looking for that kind of slow build on “The Impossible,” the English-language film from Spain based on a true story about a family’s fight to survive the 2004 tsunami in Thailand. Ewan McGregor and Naomi Watts, who received a Best Actress nomination from SAG recently, star.


Summit is releasing it Friday in 15 theaters in New York, Los Angeles, Chicago, Philadelphia, Phoenix, San Francisco, Washington, D.C., and Toronto. The plan is to go nationwide early next year.


“The Impossible” already has taken in $ 52 million in Spain, the home of the real-life couple upon whom the story is based as well as director Juan Antonio Bayona (“The Orphanage”) and screenwriter Sergio Sanchez.


Other limited rollouts set for Friday include Paramount‘s 3D concert film “Cirque du Soleil: Worlds Away,” in 800 theaters; “On the Road,” IFC Films’ adaptation of the Jack Kerouac’s beat generation novel, in four theaters; and “Not Fade Away,” the Paramount Vantage tale of a group of 1960 New Jersey friends launching a rock band, written and directed by “Sopranos” creator David Chase, in three locations.


Sony’s “Zero Dark Thirty,” about the manhunt for Osama bin Laden, got off to a terrific start Wednesday. It racked up $ 124,848 from five theaters in its first day of release. That’s an average of $ 24,969, making it one of the biggest limited mid-week openings in history.


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New Whole Plant Therapy Shows Promise as an Effective and Economical Treatment for Malaria in Research Led by Worcester Polytechnic Institute






Research Published Today in PLOS ONE May Point the Way Toward a New Model for Malaria Treatment That Could Also Be a Socioeconomic Stimulus for Developing Nations.


Worcester, Mass. (PRWEB) December 20, 2012






In the worldwide battle to curtail malaria, one of the most prevalent and deadly infectious diseases of the developing world, drug after drug has fallen by the wayside as the malaria parasite has become resistant to it. Only artemisinin, derived from the sweet wormwood plant, Artemisia annua, remains as an effective treatment, but it is expensive to produce (particularly when combined with other antimalarial medications to make it less prone to resistance) and is frequently in short supply.


A new study by scientists at Worcester Polytechnic Institute (WPI) and the University of Massachusetts has shown that the powdered dried leaves from the Artemisia annua plant may be a far more effective antimalarial treatment than purified artemisinin, delivering 40 times more artemisinin to the blood and reducing the level of parasite infection more completely in mice. The effectiveness of the whole plant, versus the purified drug, may be due, in part, to the presence in Artemisia annua leaves of other compounds, including flavonoids also known to have antimalarial abilities, which may create a combination therapy that works synergistically to combat the parasite and ward off resistance.


These are some of the conclusions of a paper titled “Dried whole plant Artemisia annua as an antimalarial therapy,” published online today by the journal PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0052746).


Using the dried whole plant, instead of purified artemisinin, could significantly lower the cost of treating malaria, since it would eliminate the need to extract the drug from the plant and purify it, and could greatly expand access to antimalarial therapy, according to Pamela Weathers, professor of biology and biotechnology at WPI and a co-author of the new study. “Artemisia can be grown readily in most climates,” she says. “It is a relatively simple process to harvest the leaves, pulverize them, test samples for their potency, measure out doses, and put them in capsules. This could become the basis for local businesses and be a wonderful socioeconomic stimulus in developing countries.”


Weathers has been studying the antimalarial abilities of Artemisia annua for more than two decades. She first described the efficacy of using of the whole plant as an antimalarial treatment in a 2011 paper published in Photochemistry Reviews. In the latest study, a high-yield cultivar of the plant developed in her lab was administered to mice by her team, led by Stephen Rich, a molecular parasitologist at the University of Massachusetts Amherst. The effects of the whole plant therapy were compared to the effects of comparable doses of pure artemisinin.


The researchers found that mice receiving a dose of the dried leaves containing a low level of artemisinin showed a significantly greater reduction in blood-borne parasites over the course of 12 to 72 hours than mice receiving the same dose of the pure artemisinin drug. When plant material containing a high level of artemisinin was given to mice, the whole plant was as effective as a high dose of the drug in clearing parasites from the blood. Interestingly, plant material with a low level of artemisinin was as effective in killing parasites as a high dose of the drug, although its effects seemed to wane after 72 hours, suggesting that multiple doses would be necessary to fully treat a malarial infection.


Weathers says the effectiveness of the whole plant treatment seems to be due, in part, to the fact that artemisinin from the dried leaves enters the bloodstream far more readily than the pure drug. “In our 2011 study, we showed that it takes about 40 times less artemisinin to achieve a comparable blood serum level when the compound is administered in the form of the whole plant,” she says. “This is consistent with the results of earlier studies in which people consumed teas made from whole leaves from Artemisia annua.”


Weathers says the effectiveness of using the whole plant as a therapy is likely a product of the plant’s complex biochemistry. “The leaves of Artemisia contain a host of compounds that are of interest for their apparent but lesser antimalarial abilities,” she says. “These include at least six flavonoids that have been shown to work synergistically with artemisinin to kill malaria parasites. This makes the artemisia leaves a combination therapy all by themselves. In fact, we have referred to the whole plant as pACT (plant Artemisinin Combination Therapy), to distinguish it from the Artemisinin Combination Therapies (ACT) that are now recommended for malaria treatment by the World Health Organization.


Artemisia annua is classified as a “generally regarded as safe” (GRAS) herb that has been consumed by humans and used as an herbal therapy for thousands of years. Weathers says she has been actively working for several years to establish the foundation for a new model for using whole plant therapy to combat malaria. She said she envisions local operations where farmers would grow the high-producing cultivars of Artemisia she and others have developed as a supplemental crop and deliver the leaves to processing stations, where they would be dried, pulverized, and homogenized, and where the powder would be placed in capsules or compacted into tablets.


“By decentralizing the production of pACT, and giving local farmers and business people the opportunity to earn a living from producing it, we will not only make an effective therapy broadly available at an affordable price, we will help stimulate the economies of developing nations. It is exciting to be involved with a project that can be beneficial in so many ways.


“When you consider that artemisinin and some of the flavonoids in Artemisia annua have been to have a therapeutic effect against host of other diseases, including Leishmania, schistosomiasis, and other ailments that are serious health hazards in the developing world, the long-term possibilities of this research grow exponentially.”


This work was funded by the UMass Medical School Center for Clinical and Translational Science and Worcester Polytechnic Institute.


About Worcester Polytechnic Institute


Founded in 1865 in Worcester, Mass., WPI was one of the nation’s first engineering and technology universities. Its 14 academic departments offer more than 50 undergraduate and graduate degree programs in science, engineering, technology, business, the social sciences, and the humanities and arts, leading to bachelor’s, master’s and doctoral degrees. WPI’s talented faculty work with students on interdisciplinary research that seeks solutions to important and socially relevant problems in fields as diverse as the life sciences and bioengineering, energy, information security, materials processing, and robotics. Students also have the opportunity to make a difference to communities and organizations around the world through the university’s innovative Global Perspective Program. There are more than 30 WPI project centers throughout North America and Central America, Africa, Australia, Asia, and Europe.


Contact:



Michael Dorsey, Director of Research Communications



Worcester Polytechnic Institute



Worcester, Massachusetts



508-831-5609, mwdorsey(at)wpi(dot)edu



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Europe Needs Less Financial Integration, Not More






“More Europe” is always the solution when leaders like German Chancellor Angela Merkel talk about Europe’s slow-burning financial crisis. To qualify for emergency aid, they say, countries like Greece and Spain must surrender control of their banks and budgets to supra-national authorities. Another brick of the “more Europe” edifice was cemented into place on Dec. 13 when finance ministers of the 17-nation euro zone agreed to unified banking supervision under the European Central Bank. That’s a step toward a banking union, which is a step toward fiscal union, which is a step toward, someday, political union.


But it’s hard to see the way to a United States of Europe when every move in that direction has Europeans at each other’s throats. Thousands of protesters took to the streets in Madrid and Barcelona on Dec. 17 in the latest demonstrations against austerity. Germans, meanwhile, complain that they’re being played for suckers by Spain and Greece. In a November poll, 46 percent of Germans favored letting Greece go bankrupt.






If ordinary Europeans balk at forming one happy family, must Europe disintegrate? Or is there a middle ground that would retain many of the advantages of unity while dodging the parts that make everybody mad? The coming year may answer the question of whether Euro Lite is a way out for the union or another false hope.


Some analysts argue that stopping short of full financial integration could make Europe more stable, not less. Avinash Persaud, chairman of Intelligence Capital Limited, a London-based financial adviser, says the real problem regulators need to address is controlling the booms rather than cleaning up after the busts. National regulators, he argues, might do a better job than a single, Europe-wide regulator of stopping excessive lending in one part of Europe. They weren’t vigilant enough in the last bubble, but Persaud is concerned that the European Central Bank will do worse. Its job is to promote commonality, making it “inherently averse” to enforcing tougher lending criteria in boom countries, he says. “Banks would pounce on rules limiting their lending in booming countries, accusing the regulator of fragmenting the single market,” Persaud said in an e-mail message. “The reins holding back the booms, already too loose, have just been loosened further” by the creation of a single banking supervisor, Persaud writes in an as-yet-unpublished article. “The euro,” Persaud says, “needs to be saved from the Europhiles.”


Another “less Europe” proposal would introduce national currencies alongside the euro. Mazen Skaf, a partner and managing director in the consulting firm Strategic Decisions Group, argues in a new white paper that nations such as Greece and Spain should have the option to issue new currencies for domestic transactions, including payment of salaries and benefits. Through a controlled depreciation, the nation’s labor and pension costs would fall. External debts would still be in euros. The plan would give countries “maneuvering space to drive monetary and fiscal policy on a local basis,” Skaf argues.


None of this is easy. Barry Eichengreen, an economist at the University of California at Berkeley who studies financial crises, says investors would regard the partial reintroduction of national currencies as a prelude to leaving the euro entirely—and yank their money out. He’s also skeptical of Persaud’s national-level regulation. He says a single bank supervisor would do a better job of spotting cross-border problems, such as the inflating of Spain’s and Greece’s bubbles by loans from German banks.


af97d  econ europe52  01inline  405 Europe Needs Less Financial Integration, Not More


Finding the right balance between national sovereignty and a tighter union for Europe is the trick. Take banking regulation. Once the euro was introduced, a banking union with a lender of last resort became the logical next step: National central banks can’t bail out their economies once they don’t have their own currencies to lend. But Merkel and the Germans won’t go along with a bank bailout mechanism financed by euro-zone governments unless there’s fiscal union—i.e., shared budgets. Right now Europe is very far from sharing a budget. Spending by the European Union accounts for only 1 percent of the EU’s gross domestic product, vs. 23 percent for federal spending in the U.S. Eichengreen suggests the EU’s budget might expand to perhaps 4 percent of GDP—enough to shore up national unemployment insurance funds in times of severe recession or to fix or close banks as needed. Spending on that scale probably wouldn’t require approval by “a European Parliament that acquires all the powers of a full parliament,” he says.


Jean Pisani-Ferry, director of Bruegel, a Brussels-based think tank, sees both sides. He says Europe’s monetary union is unstable without banking and fiscal union. He also says believers in more integration “shouldn’t use any opportunity to push for … building a federal Europe. You should look at what is necessary for the euro to work.” For Europe, that balancing act isn’t going away.


The bottom line: Economists on both sides of the Atlantic are searching for a middle ground that would save the euro without going all the way to full union.


Businessweek.com — Top News





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Wounded presage health crisis for postwar Syria






ATMEH, Syria (AP) — A baby boy joined the ranks of Syria’s tens of thousands of war wounded when a missile fired by Bashar Assad‘s air force slammed into his family home and shrapnel pierced his skull.


Four-month-old Fahed Darwish suffered brain damage and, like thousands of others seriously hurt in the civil war, he will likely need care well after the fighting is over. That’s something doctors say a post-conflict Syria won’t be able to provide.






Making things worse, there has been a sharp spike in serious injuries since the summer, when the regime began bombing rebel-held areas from the air, and doctors say a majority of the wounded they now treat are civilians.


This week, Fahed was recovering from brain surgery in an intensive care unit, his head bandaged and his body under a heavy blanket, watched over by Mariam, his distraught 22-year-old mother.


She said that after her first-born is discharged from the hospital in Atmeh, a village in an area of relative safety near the Turkish border, they will have to return to their village in a war zone in central Syria.


“We have nowhere else to go,” she said.


Even for those who have escaped direct injury, the civil war is posing a mounting health threat. Half the country’s 88 public hospitals and nearly 200 clinics have been damaged or destroyed, the World Health Organization says, leaving many without access to health care. Diabetics can’t find insulin, kidney patients can’t reach dialysis centers. Towns are running out of water-purifying materials. Many of the hundreds of thousands displaced by the fighting are exposed to the cold in tents or unheated public buildings.


“You are talking about a public health crisis on a grand scale,” said Dr. Abdalmajid Katranji, a hand and wrist surgeon from Lansing, Michigan, who regularly volunteers in Syria.


No one knows just how many people have been injured since the uprising against Assad erupted in March 2011, starting out with peaceful protests that turned into an armed insurgency in response to a violent government crackdown.


More than 43,000 have been killed in the past 21 months, said Rami Abdul-Rahman, head of the Britain-based Syrian Observatory for Human Rights, basing his count on names and details provided by activists in Syria. He said the number of wounded is so large he can only give a rough estimate, of more than 150,000.


Casualties began to rise dramatically at the start of the summer. At the time, the regime, its ground troops stretched thin, began bombing from the air to prevent opposition fighters from gaining more territory.


Seemingly random bombings have razed entire villages and neighborhoods, driving terrified civilians from their homes, with an estimated 3 million Syrians out of the country’s population of 23 million now displaced.


About 10 percent of the wounded suffer serious injuries and many of those will need long-term care and rehabilitation, said Dr. Omar Aswad of the Union of Syrian Medical Relief Organizations, an umbrella for 14 aid groups.


This includes artificial limbs and follow-up surgery. “This is of course not available and will be one of the major (health) problems in the months right after the war,” said Mago Tarzian, emergency director for the Paris-based Doctors Without Borders.


For now, aid groups are struggling to provide even emergency treatment in under-equipped clinics.


The two dozen small hospitals and field clinics in rebel-run areas of Idlib province in the north only have a few Intensive Care Unit beds between them, said Aswad. None has a CT scanner, an important diagnostic tool.


“We need generators, we need medical supplies and the most pressing is medicine,” he said.


The challenge has been compounded by new types of injuries.


The regime has begun dropping incendiary bombs that can cause severe burns, according to the New York-based Human Rights Watch, citing amateur video and witness accounts.


Ole Solvang, a researcher for the group, said he saw remnants of such a bomb on a recent Syria trip. Aswad said doctors in Idlib and nearby Aleppo province reported seeing patients with burns from such weapons.


Doctors and hospitals have also been targeted. Aswad, who fled the city of Idlib in March after regime forces entered it, said five friends in a secret association of anti-regime physicians have been arrested. Hospitals, ambulances and doctors have been attacked, Solvang said, calling it “a worrying trend that makes the medical situation even worse.”


One of the bright spots is a 50-bed emergency care clinic set up six weeks ago in a former elementary school in Atmeh.


Largely funded by a wealthy Syrian expatriate, the Orient clinic, with five ICU beds, handles some of the most serious cases in a radius of some 150 kilometers (90 miles), said its director, orthopedic surgeon Abdel Hamid Dabbak.


In the past, seriously wounded patients had to go to Turkey, risking dangerous delays at the border, he said. Now, once patients are stabilized in Atmeh, they are sent to a sister clinic across the border for follow-up care.


In Orient’s ICU, a 24-year-old rebel fighter was breathing oxygen through a mask. He had been brought in a day earlier, bleeding heavily from stomach wounds and close to death, said Dr. Maen Martini, a volunteer physician from Joliet, Illinois. After surgery, he stabilized and was taken off a respirator. A delayed crossing into Turkey would have killed him, Martini said.


The fighter’s neighbor was little Fahed, whose house had been struck by a missile on Saturday in the village of Kafr Zeita in Hama province. “The roof collapsed on us,” his mother said of the attack. “We ran out … I saw him bleeding from his head, but it was just a small cut.”


The local clinic said the injury was more serious than it seemed and the family rushed to Atmeh, more than 100 kilometers (60 miles) to the north.


Since surgery, Fahed has been nursing and has moved his arms and legs, and the doctor is hoping for a near-complete recovery.


“Clinically, he has improved dramatically,” he said.


Middle East News Headlines – Yahoo! News





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New Online Privacy Loophole Lets Facebook Advertise to Kids






Mark Zuckerberg‘s been eager to find a way to get more kids on Facebook for years, and on Wednesday, the Federal Trade Commission handed it to him on a platter. That might be overstating it a little bit. It’s more like the FTC served it to him on a platter covered in plastic wrap with a note attached that says “Do not open.” Nevertheless, should Facebook decided to see what’s inside, experts in online privacy for children say the social network could legally start peddling everything from kids’ bicycles to that new gender-neutral Easy Bake Oven.


RELATED: German Official Urges Citizens to Stop Using Facebook






After months of deliberating and plenty of lobbying on both sides of the issue, the FTC updated the controversial Children’s Online Privacy Protection Act (COPPA) this week. The changes were absolutely designed to better protect children in the privacy-invading era of social media, especially from the data-hungry advertisers who want to sell them things. Websites like Facebook don’t allow kids to sign up without their parents permission, generally because COPPA has prohibited them from collecting the kinds of information they need to serve them ads. And why would they want a user to whom they couldn’t serve ads? Under the new FTC rules, parental permission is required for just about anything a kid would do on Facebook, including uploading photos, videos and geolocational information. Tracking tools like cookies are also verboten without a parent’s permission.


RELATED: What Police Learn About You When They Subpoena Your Facebook Account


But there’s a loophole. The new rules say very plainly that no parental permission is needed “for the sole purpose of supporting the website or online service’s internal operations, such as contextual advertising, frequency capping, legal compliance, site analysis, and network communications.” The key phrase there is “contextual advertising,” which is an ad product Facebook has been working on for a while. Facebook’s version basically reads your News Feed and shows you ads that are relevant, or contextual, to what you’re reading. As a few people have pointed out, this opens a door for Facebook to start exploring the idea of ad-supported profiles for kids. Alan Simpson, the vice president of child privacy advocacy group Common Sense, isn’t happy about this idea. “Common Sense doesn’t like this part, and the industry lobbyists probably do,” he told TechCrunch Monday evening.


RELATED: What Facebook Does to Kids’ Brains


Now, there are a lot of ifs in this scenario. Based on the magnitude and sensitivity of the issue, Facebook probably doesn’t want to go scaring a bunch of parents by sneaking through loopholes to show their kids Easy Bake Oven ads. It has been nearly a decade and a half since COPPA got an update, though, and Mark Zuckerberg isn’t really known for his patience. Of course, Facebook could do what they’ve been doing for ages, which is look over their shoulder while kids lie about having permission and sign up anyways.


Social Media News Headlines – Yahoo! News





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